Cell Responsive Hydrogels Project Details
Inspired by how forces in tissue guides matrix deposition and release of sequestered molecules, we aim to develop bioinspired chemistry where an applied force facilitates biomolecule immobilisation and/or release through distinct chemical handles built into the synthetic hydrogel network. This involves the development of linkages that are amenable to crosslinking within virtually any hydrogel material to build-in dynamic functionality through applied compression or tension.
- Representative publications
- Pavithra Jayathilaka, Thomas Molley, Yuwan Huang, Shariful Islam, Michael R Buche, Meredith Silberstein, Jamie J. Kruzic, and Kristopher Kilian, Force-mediated molecule release from double network hydrogels, Chemical Communications, 2021, 57, 8484 - 8487
- Junmin Lee, Meredith N. Silberstein, Amr A. Abdeen, Sang Yup Kim, and Kristopher A. Kilian, Mechanochemical functionalization of disulfide linked hydrogels, Materials Horizons, 2016, 3, 447-451
- Junmin Lee, Amr A. Abdeen, Xin Tang, Taher A. Saif, and Kristopher A. Kilian, Geometric guidance of integrin mediated traction stress during stem cell differentiation, Biomaterials, 2015, 69, 174-183