Cell And Matrix Engineering Overview
Cell state in tissue is ruled by a multivariate presentation of signals that orchestrate diverse forms and functions. Using hydrogel microengineering we are exploring how biochemical (matrix composition and presentation), biophysical (geometry, topography, and viscoelasticity), and biological (paracrine and juxtacrine signals) cues in the cell and tissue microenvironment orchestrate cell state, matrix synthesis, and hierarchical assembly.
- Representative publications
- Junmin Lee, Amr A. Abdeen, Jamila Hedhli, Kathryn L. Wycislo, Iwona Dobrucka, Timothy M. Fan, Lawrence W. Dobrucki, and Kristopher A. Kilian, Melanoma topology reveals a stem-like phenotype that promotes angiogenesis, Science Advances, 2017, 3(10), e1701350
- Amr A. Abdeen, Jared B. Weiss, Junmin Lee, and Kristopher A. Kilian, Matrix composition and mechanics directs pro-angiogenic signaling from mesenchymal stem cells, Tissue Engineering, Part A, 2014, 20 (19-20), 2737-2745.
- Junmin Lee, Amr A. Abdeen, Douglas Zhang, and Kristopher A. Kilian, Directing stem cell fate on hydrogel substrates by controlling cell geometry, matrix mechanics and adhesion ligand composition, Biomaterials, 2013, 34, 8140-814